Glottiphyllum depressum grows in the Little Karoo in semi-arid winter rainfall veld, often close to shrubs that provide partial shade. The leaves tend to lie on the ground in two opposite rows.
The yellow flowers of several species of this genus are rather similar. The leaves give clues of identity, but are also variable. Flower diameter of G. depressum is about 5 cm.
The spongy fruit capsules of some Glottiphyllum plants tend to fall off and open after rain, releasing their seeds.