The yellow flower of Aizoon karooicum forms a cup containing a multitude of stamens that present their anthers just above the level of the five spreading petal lobes. The perianth lobes are fused at the base and spreading to reach a diameter of 1 cm.

Flowering happens in autumn and early winter (Vlok and Schutte-Vlok, 2010; iSpot; Bond and Goldblatt, 1984).