Aizoon karooicum is a sprawling dwarf shrublet in the Aizoaceae family reaching heights between 5 cm and 20 cm. The sparsely branched plant becomes woody and is much grazed.

The distribution includes the Little Karoo, extending to the west as far as Robertson and Bredasdorp, to the east into the Eastern Cape. The habitat is quartzite areas and sandy lowland flats. This plant is not considered threatened in its habitat early in the twenty first century (Vlok and Schutte-Vlok, 2010; iSpot; Bond and Goldblatt, 1984).