The leaves of Anisotoma pedunculata are simple, growing on petioles of variable length, but shorter than 2 cm. The leaves are opposite, heart-shaped, oval to almost round with entire margins. Five conspicuous veins radiate from the deeply lobed leaf base across the leaf surface. The leaf margin is entire and leaves are finely hairy.

Southern Africa has two endemic species of Anisotoma. Apart from the plant discussed here, there is A. cordiifolia. Cordiifolia means heart-shaped leaves, indicating a similar shape to the ones in the picture (iSpot; JSTOR).